- Advertisement -
Monday, February 6, 2023
Home Business Entact Bio Raises $81 Million in Series A Financing; Plans to Build...

Entact Bio Raises $81 Million in Series A Financing; Plans to Build Upon a Groundbreaking Way of Treating Problematic Proteins

Surely, there is no end to everything human beings can do, and yet there is little we do better than growing on a consistent basis. This tendency to improve under all circumstances has enabled us to hit upon some huge milestones, with technology appearing as a major member of the stated group. The main reason why technology enjoys such an esteemed stature among people is down to its skill-set, which ushered us towards a reality that we couldn’t have imagined otherwise. Nevertheless, if we look beyond the surface, it should become clear how the whole runner was also very much inspired by the way we applied those skills across a real-world environment. The latter component was, in fact, what gave the creation a spectrum-wide presence, including a timely appearance on our healthcare block. Technology’s foray into healthcare was perfectly timed, as it came right when the sector was beginning to struggle against its own outdated structure. This reality, fortunately for us, went through a complete overhaul under the new regime, but even after reaching so far, the new and budding medtech concept will somehow continue to produce all the right goods. The same has only turned more and more evident over the recent past, and truth be told, a new piece of funding does a lot to keep that trend alive and kicking.

Entact Bio, the company pioneering the development of precision medicines that enhance the function of key proteins, has successfully secured over $81 million in Series A financing. Co-led by Qiming Venture Partners USA and venBio Partners, the round saw further participation coming from the likes of Abingworth, Brandon Capital, Janus Henderson Investors, Logos Capital, Surveyor Capital (a Citadel company), and WEHI (Walter and Eliza Hall Institute of Medical Research), 4BIO Capital, and Arkin Bio Ventures. According to certain reports, the company will use the newly-raised cash to advance its proprietary Encompass™ platform, which is designed to develop enhancement-targeting chimeric (ENTAC™) molecules. But what are these ENTAC molecules? Well, ENTACs are those elements that enhance protein function by harnessing the power of enzymes called deubiquitinases, or DUBs, which are key regulators of proteins in the cell. By doing so, ENTACs are able to remove any disease-causing molecular tag from a particular protein, and therefore, achieve the desired therapeutic effect without disposing the whole protein altogether. You see, most therapies within this niche are focused on either blocking the problematic protein or degrading it. Entact, through its approach of preserving the protein, conceives a method that could offer a new way to treat various diseases, such as cancer, haploinsufficiencies, and more

Interestingly enough, though, protein enhancement isn’t the only therapeutic avenue in play here. To give you some context, many diseases arise when proteins are in the wrong location in cells. Hence, what Enact does here is that it, once again, uses DUBs to selectively shorten the molecular chain, which subsequently changes where in the cell the protein goes.

“Our aim is to provide new options for patients by developing precision medicines that enhance the function of beneficial proteins rather than eliminating or blocking proteins that contribute to disease,” said Victoria Richon, CEO of Entact Bio. “To transform this vision into reality, we have built Encompass, a proprietary platform for creating therapeutics that harness the cell’s mechanism for enhancing protein function. These ENTAC medicines will make an important difference for patients whose needs aren’t adequately met by today’s treatments.”

Entact isn’t the first organization to have leveraged DUBs for treating various disease-causing proteins, as players like Stablix Therapeutics, Vicinitas Therapeutics, and more notably, University of Berkeley have already dipped their toes in the subject. However, the stated funding should allow Entact to secure a unique spot for itself sooner rather than later.

Must Read

Data Sciences in the Medical Industry: How powerful is it?

When novel compounds were researched about, to meet the needs of patients who were in critical conditions, medical science had huge growth....

Innovative Technologies Accelerating First-In-Human to Proof-of-Concept

During the earliest stages of clinical drug development, pharmaceutical and biotech companies need to make critical go / no-go decisions for their investigational products....

Developing Animal Free Organoid Models for Drug Discovery

There is an increasing drive within the pharmaceutical and personal care communities to reduce, if not eliminate, the use of animals in the testing...

Related News

Disrupting the Pharmaceutical Space Like Never Before

The human arsenal has a lot more to it than we usually acknowledge, and yet it doesn’t boast a feature more valuable than that...

Weaving a More Informed Healthcare Space

The human arsenal is known for a myriad of different things, but most importantly, it is known for getting better on a consistent basis....

Addressing a Big Old Plague

While the human arsenal has proven itself to be pretty much limitless, it still doesn’t possess anything more valuable than that tendency of ours...

Doubling Down on the Push to Enhance Mental Health

The human arsenal has always been a little on the loaded side, but if we being honest, it is still yet to possess anything...

Strengthening an Indispensible Pillar of Our Healthcare System

Human beings are known for many different things, but most importantly, we are known for getting better on a consistent basis. This tendency to...